Humanizing the Problem of Transplant Vasculopathy

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Humanizing the problem of transplant vasculopathy.

A frequent problem in transplantation is allograft survival, which can be exacerbated by nonimmune mechanisms in response to perioperative injury of the blood vessels.1 In addition to inflammatory responses, nonimmune mechanisms may also contribute to the development of graft arteriosclerosis (GA), found frequently in cardiac allografts.2 GA of the coronary arteries, or cardiac allograft vascul...

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Allograft Vasculopathy Versus Atherosclerosis Antibody and Complement in Transplant Vasculopathy Cytokines, Interferon- , and Transplant Vasculopathy Chemokines and Transplant Vasculopathy Stem Cells and Transplant Vasculopathy

Advances in immunosuppression have decreased the incidence of acute rejection, but the development of vasculopathy in the coronary arteries of transplants continues to limit the survival of cardiac allografts. Transplant vasculopathy has also been referred to as accelerated graft arteriosclerosis because it has features of arteriosclerosis, but it is limited to the graft and develops over a per...

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Allograft Vasculopathy Versus Atherosclerosis Stem Cells and Transplant Vasculopathy Vascular Remodeling and Transplant Vasculopathy Cytokines, Interferon- , and Transplant Vasculopathy Chemokines and Transplant Vasculopathy Antibody and Complement and Transplant Vasculopathy

Over the last 4 decades, heart transplantation (HTx) has evolved as a mainstream therapy for heart failure. Approximately half of patients needing HTx have organ failure consequent to atherosclerosis. Despite advances in immunosuppressive drugs, long-term success of HTx is limited by the development of a particular type of coronary atherosclerosis, referred to as cardiac allograft vasculopathy ...

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Chemokines and transplant vasculopathy.

Transplant vasculopathy (TV) remains the leading cause of late death among heart transplant recipients. Transplant vasculopathy is characterized by progressive neointimal proliferation, leading to ischemic failure of the allograft. Multiple experimental and clinical studies have shown that injury to the graft at various stages of transplantation can be a risk factor for development of transplan...

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ژورنال

عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology

سال: 2012

ISSN: 1079-5642,1524-4636

DOI: 10.1161/atvbaha.111.241562